Fan Deming academician Cancer Research issued a statement about inflammation and cancer
December 30, 2016 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, the research team led by Fan Deming, an academician of the Chinese Academy of Engineering, published a new research progress in the international academic journal Cancer Research. In this study, they explained how the pro-inflammatory signaling pathway promotes cancer cells during the induction of gastric cancer by H. pylori. Proliferation and survival. The study provides some new grounds for a comprehensive understanding of the molecular links between inflammation and cancer.
The molecular association between inflammation and cancer is currently unclear, but this association has very important pathological implications. The JAK2/STAT3 signaling pathway activated by IL-6 and other pro-inflammatory cytokines has attracted the attention of many researchers as a key molecular pathway in the pathogenesis of cancer, but the molecular basis of activation of this pathway in cancer cells has not yet Get a full understanding.
In this study, the researchers reported that the feedback loop of IL-6 activation and its downstream target gene, CypB, regulate the growth and survival of gastric cancer cells, and STAT3 mediates the inhibition of miR-520d-5p in this loop. The researchers also found an increase in CypB expression and a STAT3 activation in clinical samples from patients with gastric cancer.
Through mechanism studies, the researchers found that miR-520p-5p is a regulator of CypB mRNA.
This signal axis regulates gastric cancer growth by altering the phosphorylation level of STAT3, and miR-520p-5p is a direct target of STAT3, and IL-6-mediated inhibition of miR-520p-5p is dependent on STAT3 activity.
In summary, the study found a positive feedback loop that promotes the effects of Helicobacter pylori on gastric cancer, including activation of the pro-inflammatory IL-6 signaling pathway, which has implications for understanding the molecular association between inflammation and cancer. It also provides a new direction for targeting inflammatory signaling pathways to achieve cancer treatment goals.
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