Male late childbearing increases fetal risk
November 23, 2018 Source: Chinese Journal of Science and Technology
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The view that older pregnant women have an adverse effect on the fetus has been widely accepted, but will the age of men also affect the health of the fetus? Recently, researchers at Stanford University School of Medicine have provided answers by collecting data on the births of babies in the United States for nearly a decade: male late childbearing increases the risk of birth, and even affects women's health during pregnancy.
“We usually assess maternal-related birth risk through maternal factors, but this study suggests that obtaining a healthy baby is not a single activity for the mother, and the age of the father has an impact on the health of the baby.†Stanford University Medicine Michael Eisenberg, associate professor of urology, said.
Studies have shown that older men over the age of 35 have higher risks at birth, such as low body weight and epilepsy. Usually the older the father is, the higher the risk. For example, when a man is over 45 years old, a 14% chance of having a premature birth will occur. When a man is over 50 years old, 28% of the baby may need to be admitted to the neonatal intensive care unit.
According to Eisenberg, these numbers do not completely prevent people from planning for future generations because these risks are still relatively low.
As early as 2017, Eisenberg published a study saying that the number of older males is growing. About 10% of babies are now from fathers over the age of 40, which was only 4% 40 years ago. “This change has no differences in race, education and geographic location. It is therefore becoming more and more important to understand the health effects of older men on future generations and pregnant women.â€
To this end, the 40.5 million birth records used by Eisenberg and colleagues came from a data-sharing project run by the US Centers for Disease Control and Prevention and the National Center for Health Statistics. The researchers were classified according to the age of men and were classified as under 25 years old, 25 to 34 years old, 35 to 44 years old, 45 to 55 years old, and 55 years old or older. The researchers excluded other factors that could influence the association between father's age and fetal outcomes, such as race, education, and smoking history.
Studies have shown that once a father reaches the age of 35, the risk of birth is increased. As male ages increase year by year, male sperm have an average of two DNA mutations per year. The risk of birth of a baby shows a rapid increase with the growth of the father.
Compared with men aged 25 to 38, men over the age of 45 are 14% more likely to have children into the neonatal intensive care unit, 14% more likely to have a premature birth, 18% more likely to have epilepsy, and a lower birth weight. It is 14% higher. If the father is 50 years of age or older, the chance of a newborn needing respiratory assistance increases by 10%, and the chance of entering a neonatal intensive care unit increases by 28%.
“What’s even more bizarre is that there is a correlation between the age of men and the risk of developing diabetes in women during pregnancy.†Eisenberg said that when men over 45 are more likely to have diabetes during pregnancy than men aged 25-34, 28%.
In the future, Eisenberg attempts to determine the possible biological mechanisms by studying other populations to determine the relationship between age and birth risk.
Treat Pharyngeal Extract,Therapeutic Pharyngeal Extract,Red Beet Extract Betanin Powder,Plant Extract Licorice Root Powder
Shaanxi Zhongyi Kangjian Biotechnology Co.,Ltd , https://www.zyplantextract.com