Trilostane White Crystalline Powder as Anti-Tumor Drugs

Model NO.: CAS: 13647-35-3 Trilostane
CAS: 13647-35-3
Other Names: 4A, 5A, 17b)-3, 17-Dihydroxy-4, 5-Epox..
Einecs No.: 237-133-0
Appearance: White to off-White Power
Type: Antineoplastic Agents
Usage: Anti-Tumor Drugs
Trademark: SMQ
Transport Package: Special Package
Specification: SGS
Origin: Shenzhen
HS Code: 2937290090
Model NO.: CAS: 13647-35-3 Trilostane
CAS: 13647-35-3
Other Names: 4A, 5A, 17b)-3, 17-Dihydroxy-4, 5-Epox..
Einecs No.: 237-133-0
Appearance: White to off-White Power
Type: Antineoplastic Agents
Usage: Anti-Tumor Drugs
Trademark: SMQ
Transport Package: Special Package
Specification: SGS
Origin: Shenzhen
HS Code: 2937290090
Trilostane White Crystalline Powder As Anti-Tumor Drugs And Immuno suppressants
 
Quick Detail:
1. Trilostane
2. CAS: 13647-35-3
3. Purity: 98.5%min
4. Other Names: 4a,5a,17b)-3,17-Dihydroxy-4,5-epox...  
5. MF: C20H27NO3  
6. EINECS No.: 237-133-0
7. Appearance: White to off-white power    
8. Type: Antineoplastic Agents  
9. Grade Standard: Medicine Grade  
11.. Packing: As customers requirments
12: Usage: Anti-tumor drugs and immunosuppressants
 
Description:
Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.
It was withdrawn from human use in the United States market in April 1994.[3][4] The drug is available in the United Kingdom for use in humans under the brand name Modrenal and is used for treatment of Cushing's disease and for breast cancer treatment
 
Applications:
It is usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered dose inhaler (MDI), nebulizer or other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the maximal effect can take place within five to 20 minutes of dosing, though some relief is immediately seen.
 
Specifications

Test Items
Specification
Test Results

Appearance
white oralmost white,crystalline powder
Conform

Solubility
Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride.
Conform

Identification
A
The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64.
Conform

B
Infraed absorption spectrophotometry.
Conform

C
Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution.
Conform

D
An orange-red color develop in methylene chloride layer.
Conform

E
It geves reaction (a) of sulphates.
Conform

Appearance of solution
Solution S is clear and not more intensely coloured than reference solution in BY6.
Conform

Optical rotation
negative 0.10° to +0.10°determined on solution S.
+0.01°

Acidity or alkalinity
NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red.
Conform

Related substances
Impurity J ≤0.20%
Conform

Any other impurity ≤0.30%
Conform

Total impurity ≤1.0%
Conform

Boron
≤50ppm
Conform

Sulphated ash
≤0.10%
0.06%

Loss on drying
≤0.5%
0.30%

Assay(on dried basis)
98.0~101.0%
99.5%

Conclusion
The test results above BP2009
Trilostane White Crystalline Powder As Anti-Tumor Drugs And Immuno suppressants
 
Quick Detail:
1. Trilostane
2. CAS: 13647-35-3
3. Purity: 98.5%min
4. Other Names: 4a,5a,17b)-3,17-Dihydroxy-4,5-epox...  
5. MF: C20H27NO3  
6. EINECS No.: 237-133-0
7. Appearance: White to off-white power    
8. Type: Antineoplastic Agents  
9. Grade Standard: Medicine Grade  
11.. Packing: As customers requirments
12: Usage: Anti-tumor drugs and immunosuppressants
 
Description:
Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome.
It was withdrawn from human use in the United States market in April 1994.[3][4] The drug is available in the United Kingdom for use in humans under the brand name Modrenal and is used for treatment of Cushing's disease and for breast cancer treatment
 
Applications:
It is usually given by the inhaled route for direct effect on bronchial smooth muscle. This is usually achieved through a metered dose inhaler (MDI), nebulizer or other proprietary delivery devices (e.g. Rotahaler or Autohaler). In these forms of delivery, the maximal effect can take place within five to 20 minutes of dosing, though some relief is immediately seen.
 
Specifications

Test Items
Specification
Test Results

Appearance
white oralmost white,crystalline powder
Conform

Solubility
Freely soluble in water,practically insoluble or very slightly soluble in alcohol and in methylene chloride.
Conform

Identification
A
The UV absorption spectrum of the sample shows an absorption maximum at 276nm.The specific absorbance at the Maximum is55 to 64.
Conform

B
Infraed absorption spectrophotometry.
Conform

C
Chromatogram obtained with test solution (b) is similar in position color & size to the principal spot in the chromatogram obtained with the reference solution.
Conform

D
An orange-red color develop in methylene chloride layer.
Conform

E
It geves reaction (a) of sulphates.
Conform

Appearance of solution
Solution S is clear and not more intensely coloured than reference solution in BY6.
Conform

Optical rotation
negative 0.10° to +0.10°determined on solution S.
+0.01°

Acidity or alkalinity
NMT 0.4ml of 0.01M HCL is required to change the color of the indicator to red.
Conform

Related substances
Impurity J ≤0.20%
Conform

Any other impurity ≤0.30%
Conform

Total impurity ≤1.0%
Conform

Boron
≤50ppm
Conform

Sulphated ash
≤0.10%
0.06%

Loss on drying
≤0.5%
0.30%

Assay(on dried basis)
98.0~101.0%
99.5%

Conclusion
The test results above BP2009

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