Effects on the cardiovascular system
Effects on isolated heart and heart function: Heart-perfusion was performed using the Yagi-Hartung method. The Ophiopogon saponins I (crude extract) had the strongest effect in enhancing myocardial contractility, and total saponin II (relatively pure). Less than the role of total saponin I, generally in the myocardial contractility increased with cardiac output increased. High-dose total saponins I, II, and total sugar inhibit the heart, reduce myocardial contractility, cardiac output, atrioventricular block, and even stop Fu. Total saponins I, II, total sugars, and total amino acids generally had a slightly slower or unchanged heart rate, with no significant effect.
Effects of myocardial systolic amplitude in isolated guinea pig hearts: Perfusion with isolated Langendorff guinea pig hearts showed that total doses of total saponins and total amino acids in Ophiopogon can increase myocardial contractility, increase coronary flow, and inhibit myocardial ischemia at high doses. Coronary flow, but both have no effect on heart rate.
Antiarrhythmic effect and its electrophysiological properties: Ophiopogon total saponin 10mg/kg intravenously can effectively prevent or counteract the arrhythmia induced by CHCL3-Adr, BaCl2, Aco, and make the dog's coronary artery 24 hours after ventricular ligation The incidence of arrhythmia decreased from 87±8 to 57±7%. Electrophysiological experiments showed that Ophiopogon total saponin 15mg/kg can significantly reduce the Vmax of the single-phase action potentials of rabbits and shorten their APD10, APD50; Ophiopogon total saponins 50μg/ml can also cause APA of transmembrane action potentials of guinea pig papillary muscle cells. Vmax significantly decreased, APD10, APD50 significantly shortened; while ERP/APD significantly increased. Ophiopogon japonicus has an ameliorative effect on arrhythmia caused by strontium chloride, aconitine, epinephrine, and pituitrin. Magnesium sulfate 2.5g, Ophiopogon japonicus 20g diluted in 500ml glucose saline intravenously in experimental dog myocardial infarction, 6h, 24h premature drug treatment times compared with the control group, the results show that Ophiopogon contract small doses of magnesium sulfate on the heart Arrhythmia after infarction has a preventive effect.
Effect on cyclic nucleotide metabolism in experimental myocardial infarction: Anesthetize the anterior descending coronary artery with a New Zealand rabbit, cause acute experimental myocardial infarction, and inject 15 ml of Ophiopogon injection (approximately 15 g crude drug) through the ear vein. Then, with the control group, blood was collected by direct cardiac puncture immediately after the operation and at 15, 30, and 60 minutes after the operation, and plasma cAMP and cGMP were measured. Results At 15 minutes after operation, cAMP and cGMP in the control group continued to increase, and the Ophiopogon group showed a decreasing trend (P<0.05). The Ophiopogon group was still lower than the control group at 30 minutes after surgery (P<0.02), and recovered 60 minutes after surgery. To preoperative level. Changes in plasma cAMP/cGMP ratio: There was no significant difference between the two groups before surgery, and the ratio between the two groups decreased immediately after surgery; the control group continued to decrease at 4.6±1.61 and 4.57±2.01 at 15 and 30 minutes after surgery; The group was close to the preoperative level, which was 6.46±2.12 and 6.48±2.39, respectively (P<0.05). At 60 minutes after operation, the Ophiopogon group maintained the preoperative level and the control group had an upward trend. There was no significant difference between the two groups. Plasma cAMP and cGMP levels were significantly higher than normal after acute myocardial infarction. It may be a stress response, due to a large number of myocardial cell necrosis and dissolution, release of cAMP and cGMP, so that plasma levels increase, the degree of myocardial damage. As myocardial ischemia, cGMP increased more significantly than cAMP, so the cAMP/cGMP ratio decreased significantly after myocardial infarction. Ophiopogon may increase the myocardial blood flow after infarct. Myocardial cells with hypoxia and ischemia will be repaired and protected sooner. As a result, the release of cGMP and cAMP from the heart muscle will be reduced, which will reduce the plasma level and balance the two.
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