High Purity Anticancer Drug Azd-9291 (Mesylate) CAS 1421373-65-0 for for Lung Cancer

Quick Details:

Anticancer Inhibitors AZD-9291 for for Lung Cancer

AZD-9291
Synonyms:AZD9291;N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide;N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide;N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide;N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
CAS: 1421373-65-0
MF:C28H33N7O2
MW:499.61




Main Functions: 

AZD 9291 is an irreversible inhibitor of epidermal sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). AZD 9291 has been shown to inhibit tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg and has been tested clinically in patients with advanced EGFR mutant non-small-cell lung cancer.

Application:

AZD9291 administered once daily orally at 5 mg/kg caused profound regression of tumours across EGFRm+ (PC9; 178% growth inhibition) and EGFRm+/T790M (H1975; 119% growth inhibition) tumour models in vivo,
after 14 days dosing. Furthermore 5 mg/kg AZD9291 was sufficient to cause significant shrinkage of EGFRm+ and EGFRm+/T790M transgenic mouse lung tumours. Tumour growth inhibition was associated with profound inhibition of EGFR phosphorylation and key downstream signaling pathways such as AKT and ERK. Chronic long-term treatment of PC9 and H1975 xenograft tumours with AZD9291 led to a complete and sustained macroscopic response, with no visible tumours after 40 days dosing, and being maintained beyond 100 days. Furthermore, pre-clinical data also indicates that AZD9291 could target tumours that have acquired resistance to the more recently identified HER2-amplification mechanism, thus potentially extending its benefit in TKI resistant patients.
 

Our Advantage:

1. Has Oxandrol a high quality with competitive price:
   1)Standard: Enterprise Standard
   2)All Purity≥ 99%
   3)We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
   1)Parcel can be sent out in 24 hours after payment. Tracking number available
   2)Secure and discreet shipment. Various transportation methods for your choice.
   3)Customs pass rate ≥ 99%
   4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we         have stock in there for transferring.
3, We have clients throughout the world.
   1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery           meet their desire.
   2)Market feedback and goods feedback will be appreciated, meeting customer's requirement is our                       responsibility.
   3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
 

FAQ

Q1: Have your Product Quality been Approved by Third Party Lab?

A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China. So you will be assured with Good Quality if you choose us. 
 
Q2: How do you treat quality complaint?

A: First of all, our QC department will do strict examination of our export products by HPLC, UV, GC,TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: How to cooperate with us?

You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email. 

Q4: Do you Accept Sample Order?

A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q5: Is there any discount?

A: Yes, for larger quantity, we always support with better price. 

Q6: Do you accept VISA business credit card ?

A: Sorry we don't accept VISA credit card,
we'd like to accept T/T , Moneygram ,Western Union.

Q7: How long does it take to the goods arrived ?

A:It is Depending on your location,
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q8: Do you have any reshipment policy ?  

We have good after-sale service and re-shipment policy if the parcel  lose.
Our long association with  our clients has brought great benefits.
We always take the upmost care in the packaging of our products .
Our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship.

Quick Details:

Anticancer Inhibitors AZD-9291 for for Lung Cancer

AZD-9291
Synonyms:AZD9291;N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide;N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide;N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide;N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide
CAS: 1421373-65-0
MF:C28H33N7O2
MW:499.61




Main Functions: 

AZD 9291 is an irreversible inhibitor of epidermal sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). AZD 9291 has been shown to inhibit tumor growth in a xenograft mouse model at oral doses of 5-10 mg/kg and has been tested clinically in patients with advanced EGFR mutant non-small-cell lung cancer.

Application:

AZD9291 administered once daily orally at 5 mg/kg caused profound regression of tumours across EGFRm+ (PC9; 178% growth inhibition) and EGFRm+/T790M (H1975; 119% growth inhibition) tumour models in vivo,
after 14 days dosing. Furthermore 5 mg/kg AZD9291 was sufficient to cause significant shrinkage of EGFRm+ and EGFRm+/T790M transgenic mouse lung tumours. Tumour growth inhibition was associated with profound inhibition of EGFR phosphorylation and key downstream signaling pathways such as AKT and ERK. Chronic long-term treatment of PC9 and H1975 xenograft tumours with AZD9291 led to a complete and sustained macroscopic response, with no visible tumours after 40 days dosing, and being maintained beyond 100 days. Furthermore, pre-clinical data also indicates that AZD9291 could target tumours that have acquired resistance to the more recently identified HER2-amplification mechanism, thus potentially extending its benefit in TKI resistant patients.
 

Our Advantage:

1. Has Oxandrol a high quality with competitive price:
   1)Standard: Enterprise Standard
   2)All Purity≥ 99%
   3)We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
   1)Parcel can be sent out in 24 hours after payment. Tracking number available
   2)Secure and discreet shipment. Various transportation methods for your choice.
   3)Customs pass rate ≥ 99%
   4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we         have stock in there for transferring.
3, We have clients throughout the world.
   1)Professional service and rich experience make customers feel at ease, adequate stock and fast delivery           meet their desire.
   2)Market feedback and goods feedback will be appreciated, meeting customer's requirement is our                       responsibility.
   3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.
 

FAQ

Q1: Have your Product Quality been Approved by Third Party Lab?

A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China. So you will be assured with Good Quality if you choose us. 
 
Q2: How do you treat quality complaint?

A: First of all, our QC department will do strict examination of our export products by HPLC, UV, GC,TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
 
Q3: How to cooperate with us?

You can contact us for cooperation through the website contact information, or contact with the salesmen in our company. We will connect you about the specific detail via email. 

Q4: Do you Accept Sample Order?

A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.

Q5: Is there any discount?

A: Yes, for larger quantity, we always support with better price. 

Q6: Do you accept VISA business credit card ?

A: Sorry we don't accept VISA credit card,
we'd like to accept T/T , Moneygram ,Western Union.

Q7: How long does it take to the goods arrived ?

A:It is Depending on your location,
For small order, please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.
For mass order, please allow 5-8 days by Air, 20-35 days by Sea.

Q8: Do you have any reshipment policy ?  

We have good after-sale service and re-shipment policy if the parcel  lose.
Our long association with  our clients has brought great benefits.
We always take the upmost care in the packaging of our products .
Our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible  will seize a small number of packages.
In this circumstance we promise reship free  to establish  long term relationship.

our Pig Neck Loop is for the farmer to catch and hold the pig and keep it in following farmer`s way for usage .

we have different raw material of this pick Neck Loop such plasitkc handle and metal one .

it is convienece and easy to use and its price is reasonable . 

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