Interview with Gene Editor Daniel Jennifer Doudna: The application of CRISPR for immunotherapy is promising

The name Jennifer Doudna must be familiar to everyone. As one of the pioneers in the field of CRISPR, her academic and commercial achievements are obvious to all. Every year, her team will publish a number of results in top journals such as CNS. According to Doudna Labs' official website, in 2016, the research team has published more than 20 papers in the journals Cell, Nature, Science, Nature Biotechnology, and Nature Methods. The following small series counts some of the results related to genetic editing:

According to Wikipedia, Doudna "Goddess" was born in 1964 and is now a professor of chemistry, molecular and cellular biology at the University of California at Berkeley, and a researcher at the Howard Hughes Medical Institute.

In August 2012, a research team led by Doudna and French microbiologist Emmanuelle Charpentier published a paper entitled "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity" in Science, revealing the current research How does the circle's CRISPR/Cas9 system transform into a gene editing tool.

Starting with this paper, in just over 4 years, this gene editing tool has rapidly developed into a "magic pen" that rewrites the book of life. On the one hand, global scientists have made a lot of research progress with the help of CRISPR; on the other hand, several well-known CRISPR pioneers have founded companies, and these companies have been listed this year.

However, although it is expected that this disruptive technology can truly change the treatment of human diseases, a report released by Kalorama Information indicates that the current development of disease treatment based on CRISPR/Cas9 technology lags behind ZFNs and TALENs. At present, it is unclear whether CRISPR technology is suitable for the treatment of human diseases. In this regard, how do top scientists in the field of genetic editing look at it?

I am excited by this potential to use the CRISPR technology to program a patient's immune system to recognize tumor cells in a precise way.

Last month, Doudna "Goddess" accepted an interview with Cell magazine and shared her views on the treatment of CRISPR for diseases such as cancer.

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