Osaka University, Japan, says soluble microneedle stickers or replaceable vaccine injections

Release date: 2015-07-22

After the vaccination, you don't need an injection! Researchers at Osaka University in Japan reported in the journal Biomaterials that they have recently developed a microneedle patch that is soluble in the skin. Compared to standard vaccination methods, the new method makes vaccination easier and safer. Less pain.

Most vaccines are vaccinated by subcutaneous or intramuscular injection. Although this method can effectively deliver the vaccine to the human body, it requires the medical staff to have professional skills and the risk of infection or injury due to the use of a needle. The new micro-needle stick is made of soluble material, avoids the risks associated with needles, and is easy to operate without the help of trained medical staff, making it ideal for use in developing countries with limited medical resources.

According to a recent report by the Physicist Organization Network, this microneedle sticker, named MicroHyala, dissolves in water. The microneedles are made of hyaluronic acid, a natural substance that cushions the joints. When the patch is applied to the skin, the microneedle pierces the outermost layer of the skin and dissolves into the body with the vaccine.

The researchers vaccinated the two groups of volunteers against A/H1N1, A/H3N2, and B viruses by traditional injection methods and vaccine delivery via microneedle stickers. None of the volunteers showed adverse reactions, indicating that microneedle stickers can be safely applied to humans. Comparative experiments also found that volunteers using microneedle stickers showed an equivalent or even stronger immune response than injection. One of the authors, Osaka University Professor Nakagawa Shinsuke (transliteration) said: "We are very pleased to see that our new microneedle stickers are as effective as injecting flu vaccines and in some cases even better."

Previous studies have evaluated microneedles made of silicon or metal materials and found that they are not safe and there is a risk of breakage, leaving tiny fragments in the skin. The new microneedle sticker is designed to dissolve in the skin, eliminating this danger. Nakagawa said: "We have proven that microneedle stickers are safe and effective. Because it is also painless, non-trained people are also very easy to use, and we think this may bring significant impact on global vaccination methods. change."

Source: China Science and Technology Network - Technology Daily

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