US researchers recently reported in the US "Cell Report" magazine that they found that osteocalcin secreted during exercise can work with a protein to improve brain memory and reverse old-age forgetfulness.
Forgetfulness was once thought to be a single symptom. Now scientists realize that Alzheimer's disease occurs in the entorhinal cortex of the hippocampus, and the memory loss associated with aging occurs in the dentate gyrus of the hippocampus. The hippocampus is located between the cerebral thalamus and the medial temporal lobe and is responsible for the storage, transformation and orientation of long-term memory. Researchers at Columbia University and other institutions have previously found that the lack of a protein called "RbAp48" in the body causes loss of memory associated with aging, but has nothing to do with Alzheimer's disease. In mice and humans, the level of this protein decreases with age. While artificially increasing this protein in the dentate gyrus of aging mice, memory can be improved.
The new study further found in mouse experiments that this protein controls the expression levels of two other proteins, which are key components of osteocalcin signaling in the hippocampus. If the "RbAp48" protein function is inhibited, the effect of improving memory is lost. If the pathway that transmits osteocalcin to the hippocampus is activated, the "RbAp48" protein will also increase, improving memory.
The new study provides new evidence for exercise prevention to prevent forgetfulness. Mouse experiments have shown that moderate exercise such as walking promotes the release of osteocalcin in the body. Researchers believe that over time, osteocalcin will reach the brain and work with the "RbAp48" protein, which will ultimately bring long-term benefits to memory. According to Xinhua News Agency
Esophagus and Bronchoscopy Instruments
We're professional Esophagus and Bronchoscopy Instruments manufacturers and suppliers in China, specialized in providing high quality medical instruments with reasonable price. We warmly welcome you to buy or wholesale bulk Esophagus and Bronchoscopy Instruments for sale here and get quotation from our factory.
Bronchoscopy Instruments,Esophagoscopy Instruments,Bronchoscopy Biopsy Forceps,Esophagus And Bronchoscopy Instruments
Tonglu WANHE Medical Instrument Co., Ltd , https://www.vanhurhealth.com