Faster and more efficient antiviral drug development using gene editing technology
May 18, 2016 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];While scientists are accelerating research into new treatments such as Zika virus, researchers from institutions such as the California NanoSystems Institute have recently developed a high-accuracy and high-efficiency study based on gene editing technology. DNA screening systems; in order to develop new drugs against viral infections, researchers need to be aware of the mechanisms by which viruses infect healthy cells, and these underlying mechanisms may be targets for the development of new drugs.
In order to determine the mechanism or target of viral infection, scientists need to screen the DNA in the host cell to find specific genetic mutations, which are usually used by researchers to remove or knock out viral infection or replication. Genes to achieve. Recently, researcher Robert Damoiseaux has teamed up with researchers at Sandia National Laboratories to develop a special library screening method based on CRISPR technology. This new method can be carried out more than traditional methods. Effective and highly sophisticated research to help scientists find the key target genes that cause disease.
First, the researchers started with a mixture of CRISPRs, a library of multiple DNA fragments, which used high-throughput automated equipment to separate the mixture into a single component and then screened the individual components. The susceptibility genes of Zika virus in the human body can be determined in a short period of time, and then new and highly effective antiviral therapies can be designed to help the body protect against viral infections.
With the help of Sandia National Laboratory researchers, researcher Damoiseaux's research team is currently developing a CRISPR-based microarray library that will reduce the cost of antiretroviral development and accelerate the development of antiviral drugs. process. Damoiseaux said that when you use CRISPR to identify a set of genes responsible for viral replication from a mixture, you must perform a series of experiments to verify the function of each individual gene, and in this newly developed microarray library, Researchers are as easy as playing games, because this screening system can directly identify a single gene, which can help researchers capture more subtle effects than traditional methods.
At present, the microarray CRISPR library can be applied to many research fields, such as cancer therapy research. By better understanding human health, CRISPR technology can bring more unexpected discoveries to scientists, and at the same time The development of new therapies for the treatment of a variety of hereditary diseases will also bring some help and hope.
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