Freezer dryer working principle

The working principle of the refrigerating dryer is a technique of drying by using the principle of sublimation. The dried aqueous substance is rapidly frozen into a solid state at a low temperature, and then the frozen water molecules are directly sublimated in a proper vacuum environment. The process by which water vapor escapes to remove moisture and conserve material. The product obtained by freeze drying is called a lyophilizer. This process is called lyophilization.

Freezer dryer working principle

In order to ensure the biological activity and quality of the sample, the sample needs to be pre-frozen first, and then pre-freezing in a refrigerator or a refrigerating dryer and then placed on the shelf of the freeze-drying bin to carry out the main drying process of the sample. At this time, the moisture in the sample is directly sublimated into steam under the action of the low temperature and high vacuum of the refrigerating dryer, and is captured by the low temperature cold trap and the vacuum pump. After dozens of hours of main drying, most of the moisture of the sample is sublimated, and the sample is completely retained, and the sublimated gas is condensed into ice in the cold trap. Due to the pressure, gas is sublimated and then The cold trap is condensed into ice. When the ice is sublimated, it absorbs heat, causing the temperature of the sample itself to drop and slowing down the sublimation speed. In order to increase the sublimation speed and shorten the drying time, the product must be properly heated. In order to ensure the higher purity of the sample, the sample can be heated and lyophilized at this time, or the post-drying process can be performed. The sample temperature can reach room temperature, and all lyophilization processes are completed.

Advantage

1 The substance is always in a low temperature (freezing state) before drying, and the ice crystals are evenly distributed in the substance, and the sublimation process does not cause concentration due to dehydration, thereby avoiding side effects such as foaming and oxidation caused by water vapor.
2 The dry material is dry sponge with a porous volume, which is basically unchanged, without shrinkage, and is very soluble in water and returns to the form before lyophilization.
3 The principle of ordinary drying is to use heating, but these drying methods are carried out at temperatures above 0 ° C or higher, and the dried products vary greatly in physical and chemical shapes. In the process of freeze-drying, the growth of microorganisms and the action of enzymes cannot be carried out, and the original biological and chemical properties of dry substances are prevented from being largely prevented by Zui, and the stability is good, and it is easy to store for a long time.
4 The product is dried, desorbed, and tamponed in a sterile state in the freeze-drying chamber.
5 can remove 95% to 99% of the water in the substance.
6 It is especially suitable for the dry preservation of heat sensitive substances such as vaccines, strains, poisonous species, blood products and the like.
7 The main components of the lyophilizer have excellent structure layout, which is conducive to transportation, installation and production operations; it is conducive to cleaning and maintenance, and meets GMP requirements.

Features of Ningbo Shuangjia Freeze Dryer :

★ Freeze dryer automatic control system programmable freeze dryer, all freeze-drying process, from freeze-drying to defrosting, are controlled by program.
★ The diaphragm heating system controls the temperature by heating the heat generated by the separator, so the temperature uniformity is more accurate and the freeze-drying speed is increased.
★ Sample Pre-freezing System The freeze-drying chamber has a freezing system that can pre-freeze the sample before lyophilization.
★Pure nitrogen backfill system (used in biological products)
To permanently store the sample, the vacuum chamber can be filled with sterile air or nitrogen using a backfill system to protect the sample from contamination.
★Safe gland system In order to permanently store samples after lyophilization, the gland system is used under vacuum to achieve a safe and precise sealing effect.
★ Anti-vacuum pump oil reverse spray system anti-reverse spray device protects the sample and prevents the vacuum pump oil from flowing back to the system and contaminating the sample.
★ Compressor secondary delay start system: protect the compressor and extend the service life of the compressor.
★ Optional computer remote control.

★Optional USB connection function, export curve data to U disk

★ Hanging bottle function: Optional configuration of 4 freeze-dried bottles or 24 ampoule bottles, observe the dry condition of the sample at any time, no need to shut down

Due to its characteristics, freeze-drying technology has been widely used in the chemical industry, biological products, etc. SJIA has 10 years of experience in the refrigeration industry, and the developed refrigerating dryer is in the leading position in the Chinese refrigeration industry.

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