GlaxoSmithKline and Fimbrion collaborate to develop the first new antibiotic-free therapy for urinary tract infections
October 28, 2016 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];British pharmaceutical giant GlaxoSmithKline (GSK) recently announced a partnership agreement with Ficbrion Therapeutics, a US startup biotechnology company, to develop first-in-class small molecule drugs for the treatment of urinary tract infections (UTIs). prevention. These small molecule drugs are a class of modified (such as N-linked thiazolylamino) mannosides that contain mannose in their molecular structure.
Under the agreement, GlaxoSmithKline and Fimbrion will focus on the preclinical development of such small molecule compounds to explore whether such mannosides can be effectively eliminated by preventing the bacteria from adhering to the bladder wall and allowing the body to naturally clear the infection. Treat and prevent urinary tract infections without causing antibiotic resistance.
Urinary tract infection (UTI) is the third major indication for antibiotic treatment. However, with the widespread use of antibiotics, the problem of multidrug-resistant bacteria has become increasingly serious, leading to a far-reaching medical need in this field. In the future, the development of antibiotic-free therapies will become an important direction in the treatment of the increasingly common infectious disease syndrome caused by antibiotic-resistant pathogens.
It is worth mentioning that this cooperation is also the first time that the DPAc team (Discovery Partnerships with Academia) has reached a cooperation with a start-up biotechnology company. GlaxoSmithKline formed the DPAc team, which was originally designed to bring together researchers from the corporate and academic communities to establish a true partnership that transforms innovative scientific research into innovative drugs that can benefit patients.
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