Israel develops new drugs for the treatment of acute leukemia

Israel develops new drugs for the treatment of acute leukemia

August 27, 2018 Source: Xinhua Author: Chen Xian Du Zhen

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Xinhua News Agency, Jerusalem, August 25 (Reporter Chen Wenxian Du Zhen) The research team of the Hebrew University Medical School in Israel announced that they have successfully developed a new biopharmaceutical for the treatment of acute myeloid leukemia.

The team said the new drug cures 50% of mice with acute myeloid leukemia. The relevant results are published in the new issue of the American Journal of Cell. Currently, the research team and related parties are applying to the US Food and Drug Administration for a first-phase clinical trial of new drugs.

According to the researchers, most biopharmaceuticals used to treat leukemia have only played a role in a single protein in leukemia cells. However, during targeted therapy, leukemia cells can rapidly activate other proteins to block the drug, resulting in rapid proliferation of drug-resistant leukemia cells.

The new drug developed by researchers at the Hebrew University, like a "cluster bomb," can simultaneously "attack" several proteins, making it difficult for leukemia cells to activate other proteins to escape chemotherapy. The new drug also has the efficacy of several different drugs, thereby reducing the number of times cancer patients need treatment and its side effects.

Acute myeloid leukemia is a rapidly progressing, life-threatening blood disorder that affects people of all ages. In recent decades, the mainstream treatment of acute myeloid leukemia has changed little. Although a small number of patients have been cured, it is still a terminal illness for most patients.

The medical profession has been developing drugs for acute myeloid leukemia. For example, in April this year, a study published in the journal Science and Translational Medicine reported that a small protein drug is expected to be used in the treatment of acute myeloid leukemia, and has now entered clinical trials in the United States.

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