Ministry of Science and Technology released the "13th Five-Year Plan" biomedical technology innovation special plan
On May 10th, in accordance with the overall plan of the "Thirteenth Five-Year Plan for National Economic and Social Development of the People's Republic of China", "Strategic Outline of National Innovation Driven Development" and "National Science and Technology Innovation Plan of the "13th Five-Year Plan", In order to accelerate the development of biotechnology and biotechnology industry, the Ministry of Science and Technology has formulated and released the “Special Plan for Biotechnology Innovation in the “13th Five-Year Plan†(hereinafter referred to as “Planningâ€).
The Plan proposes three indicator systems for the overall goal, namely, raising the level of originality of biotechnology. Focus on the development of 20-30 leading new technologies, develop 30-50 major strategic new products, and break through 50-80 key application key technologies. Create a platform for biotechnology innovation. Promote the construction of several biotechnology innovation centers focusing on green bio-manufacturing, innovative drug research and development, and biomedical engineering; and build strategic resource platforms such as the National Bioinformatics Center, the Human Genetic Resources Database, and Bio-medical Big Data. Strengthen the industrialization of biotechnology. Create 10-20 biomedical professional parks with an output value of over 10 billion and 5-10 bio-manufacturing professional parks with an output value of over 10 billion.
The Plan also identifies key tasks, including: 1) breaking through a number of cutting-edge key technologies, 2) supporting key areas, 3) promoting innovation platforms, and 4) promoting biotechnology industry development.
First, break through some cutting-edge key technologies
"Planning" subdivides cutting-edge key technologies into three categories: disruptive technology, cutting-edge cross-technology and common key technologies. Specific technologies include: 1) next-generation bio-detection technology, 2) next-generation gene manipulation technology, 3) synthetic biotechnology, 4) brain science and brain-like artificial intelligence, 5) microbial technology, 6) nanobiotechnology, 7) Bio-imaging technology, 8) Bio-big data, 9) omics technology and 10) process engineering technology
Second, support the development of key areas
The “Planning†lists seven key areas: biomedicine, biochemical, biological resources, bioenergy, bio-agriculture, bio-environmental protection and bio-safety.
Third, promote the construction of innovation platform
The "Planning" has planned three aspects: 1. Strengthen the layout of large-scale comprehensive research bases in the field of biotechnology; Technology Innovation Center; 3. Strategic resource platform
Fourth, promote the development of biotechnology industry
The "Planning" clearly pointed out that around the Beijing-Tianjin-Hebei, Yangtze River Delta, Pearl River Delta and other universities and research institutes, the reform of the institutional mechanism and the policy will be carried out first, and the biotechnology achievements of the biotechnology contract turnover exceeding 10 billion yuan will be established. Transfer conversion demonstration area.
V. The top ten medical biotechnology in the future
1) New generation biometric technology
Develop a new generation of gene sequencing technology, pay attention to the application of single molecule technology and analysis and interpretation of sequencing data; develop single cell separation, genome amplification, transcriptome amplification and single cell genomic analysis technology; develop single molecule detection of biological macromolecules , fluorescence in situ hybridization and noise reduction technology; development of protein sequencing technology, new mass spectrometry and microfluidic chip technology; development of accurate measurement technology for genes and proteins, promoting bio-detection technology to trace, trace, single molecule, high-throughput Oriented development.
2) A new generation of genetic manipulation technology
Development of precise or quantitative new gene manipulation technologies, gene (group) editing technology for eukaryotic cells, and new microbial gene recombination technology with important application value in industrial production and environmental protection, promoting the editing of multiple genes (groups) The integration of means, pay attention to the efficiency and flux of gene manipulation, improve the ease of operation, reduce the off-target and expand the scope of application.
3) Synthetic biotechnology
Break through artificial life components, gene lines and bio-computing, artificial living organisms, artificial multi-cell system design and construction control principles, develop large-segment DNA and artificial genome design and synthesis technology, design and construct major disease diagnosis and treatment, light energy and electric energy utilization, nitrogen fixation or Carbon sequestration, or a synthetic life system of great theoretical significance, building DNA synthesis and assembly, biocomputing and design, component module chassis library sharing platform, and artificial cells that can produce chemicals, materials, natural products, drugs, bioenergy The factory seizes the commanding heights of synthetic biology strategy and leads the new bio-economic development represented by green biological manufacturing and modern biological therapy.
4) Brain science and brain-like artificial intelligence
Develop brain connection map mapping, real-time recording and regulation of neural network activities, neuron types and their specific neural loop structure and functional analysis techniques to study brain structure and function, working principle and so on. At the same time, the development of cognitive dysfunction brain disease screening and analysis techniques, the development of cognitive dysfunction brain disease prevention, diagnosis and treatment products, change the status of diagnosis and treatment of related brain diseases. Develop neural network computing, processing and storage technology based on brain working principle, as well as a new generation of intelligent technologies such as microprocessors and devices such as neural network chips and neuron sensors, and brain-computer interaction, and develop brain-like artificial intelligence devices and robots to promote the industry. And then develop intelligent social service technology and platform system.
5) Microbiome technology
To study the relationship between human microbiome and population health, to explore key microbial traits and key gene groups, to carry out microbiological research on human nutrition, to develop related products, to carry out research on plant symbiosis, rhizosphere and soil microbial groups, and to develop agricultural microorganisms. Microbial agents for microbial agents and environmental protection; research and product development of probiotics and gut microbiome for poultry and aquatic animals; research on technologies, products such as industry, environment, marine microbiology and functional regulation. Develop high-throughput and high-precision calculation methods and bioinformatics technologies for processing microbiome data, establish relevant data centers and technology platforms, and conduct large-scale microbial data integration and mining.
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