Release date: 2018-06-28
The academician of the Chinese Academy of Engineering and the Wang Xuehao team of the Hepatobiliary Center of the People's Hospital of Jiangsu Province cooperated with Johns Hopkins University in the United States to make important progress in the research of anti-cancer immunotherapy transformation. They confirmed that Yes-associated protein (YAP) can promote the development of tumors by affecting the tumor immune microenvironment, providing a new strategy for clinical tumor immunotherapy. YAP cancer antagonists and their regulatory target inhibitors may become An anti-cancer immunotherapy drug. Recently, the international academic journal "Tumor Discovery" published the research related paper online.
Regulatory T cells (Tregs) are a group of T cells that play a key role in autoimmune homeostasis. They can inhibit immune mobilization and achieve immune escape in the tumor immune microenvironment. YAP can regulate organ development. Recent studies have shown that it is closely related to tumor development and development, and is significantly increased in lung cancer, colorectal cancer, ovarian cancer, liver cancer and prostate cancer, and acts as a powerful tumor promoter in tumor progression. It plays an important role, but the mechanism of action is still unclear.
This study found for the first time that YAP is highly expressed in Tregs and is closely related to Tregs' key transcriptional protein Foxp3 expression and Treg immunosuppressive function. Foxp3 can up-regulate gene expression that promotes Tregs phenotype and function, Foxp3 Decreased can directly lead to the absence of Tregs phenotype and function. Studies have shown that YAP deletion can lead to decreased expression of Foxp3 and decreased function of Tregs, inhibiting Tregs-dependent tumor immunity.
Tumor immunotherapy has become the fourth largest cancer treatment after surgery, radiotherapy and chemotherapy. The study found that Tregs inhibit anti-tumor immunity, and intervention in these pathways may become a new target for immunotherapy. (Chief reporter Liu Zhiyong)
Source: Health News
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