Preclinical animal behavior test indicators for antidepressants

Rats and mice are commonly used in experimental animals.  
The basic principle is based on the overall animal behavior pharmacology method, based on the basic pharmacological effects of depressive drugs, the selection of neurochemical, electropharmacological, cellular and molecular biology techniques and methods for comprehensive evaluation. There are many kinds of overall models. What indicators and what needs to be paid attention to require careful experimental design. Only one outline can be drawn here, hoping to help everyone's work.  
There are several behavioral experiments:  
1 Rat forced swimming experiment  
Indicator: No time.  
Note: A should simultaneously detect the central excitatory effects of the drug and rule out false positives.  
B species are very different, and attention should be paid to the sensitivity of the germline.  
C The depth of water in the experiment is the key  
2 mouse forced swimming  
See rat  
3 mouse tail suspension method  
See 1  
4 Rat acquired helpless method  
Indicators: Number of escapes and failures and latency  
Note: This method is mostly used to observe the antidepressant effect of drugs after subchronic administration.  
5 Unpredictable long-term stress test  
Indicators: selected according to evaluation indicators. Such as spontaneous activity measurement, escape behavior determination, determination of sucrose water consumption  
note:  
The same stress should not be used multiple times  
Pay attention to species differences  
In addition, there are operational behavior models and the like.

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