Today, when bird flu is rampant worldwide, the creation of anti-bird flu chickens is a way to fight this possible storm. Studies have shown that using genetically modified technology, researchers can develop anti-bird flu chickens. The results of this study were published this week in the online edition of PNAS (Proceedings of Academy of Sciences). In addition to creating genetically modified chickens against bird flu, researchers can also use chickens to produce high levels of therapeutic proteins in their eggs. For example, genetically engineered chickens that encode human insulin genes may produce high levels of pure insulin. Benjamin B. Scott and Lois, a graduate student from MIT, proposed a more efficient method of delivering genes directly into the egg genome, making it easier to create genetically modified birds. Moreover, this transferred gene is easily activated in specific organs. In the article, the researchers reported that they used this method to create neurons that carry a fluorescently labeled transgenic mite. The traditional method of injecting DNA into the nuclei of embryos can only integrate 1% to 3% of the cells with new DNA. In 2002, Lois reported a method for producing transgenic animals by using specialized molecular machines for lentiviruses. This virus continues to efficiently integrate new DNA into the cell nucleus. So far, this vector has been used to make transgenic pigs and cattle. In the recent attempts of birds, the transgene success rate was 30% to 40%. The use of genetically modified bird models not only promotes biological and neurobiological development, but the transformation of bird genomes may also breed chickens that do not transmit diseases to humans, chickens that are resistant to common chicken diseases, and can manufacture A large number of medicinal substances such as insulin "medicinal chicken". However, Lois said that the possibility that this GM technology can really be used to create a better chicken for human consumption is very small, because the current chicken has been selectively cultivated for many years, and it is between wild chickens. The difference is so big that it's like a difference between a poodle and a wolf.
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