US-made cells with hematopoietic stem cell function are important for cell therapy and leukemia treatment
May 23, 2017 Source: Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];British "Nature" magazine published two important advances in stem cell research on the 16th. American scientists have successfully transformed human pluripotent stem cells and mouse endothelial cells into cells with hematopoietic stem cell function. The latest results are a step closer to the production of hematopoietic stem cells (HSCs) in the laboratory, and are important for the research and treatment of cell therapy, drug screening and leukemia.
Blood cells are produced by hematopoietic stem cells, which occur during embryonic development and are produced by specialized endothelial cells on the vessel wall. Hematopoietic stem cells have the long-term self-renewal ability and the potential to differentiate into various mature blood cells. It is also the longest and deepest type of adult stem cells in human history. Most leukemias are directly or indirectly related to hematopoietic stem cell abnormalities.
This time, George Dali, a researcher at Boston Children's Hospital and Dana Farber Cancer Institute, led a team that first used chemical signals to convert human pluripotent stem cells into hematopoietic endothelial cells and then changed the levels of seven key transcription factors. They are induced to become hematopoietic stem cell-like cells.
In the second paper published at the same time, Sahin Rafi and colleagues at Cornellville School of Medicine in the United States used adult mouse endothelial cells as a starting material and then changed the levels of key transcription factors to drive them to transform. A cell having the characteristics of mouse hematopoietic stem cells.
In further research, both teams used environmental signals to mature hematopoietic stem cells. The Dali team transplanted human cells into the bone marrow of adult mice, and the Raf team allowed mouse cells to grow on the embryonic endothelial cell layer. The resulting cells have all the characteristics of hematopoietic stem cells - they can be transplanted into recipients to produce a variety of different blood cell lines.
In the accompanying news and opinions, scientists at the University of Cambridge in the United Kingdom believe that although the Dali team's research focused on mice, human adult endothelial cells can be obtained from healthy donors. Experiments have shown that the cells used by the team are from donors and reprogrammed into pluripotent cells. These studies are expected to achieve personalized leukemia therapy, hematopoietic stem cells from the patient's own cells or can be used to treat leukemia.
Editor-in-chief
Hematopoietic stem cells can treat leukemia by replacing the patient's damaged cells with donor healthy stem cells. It is a pity that the number of suitable and available transplants is never sufficient, so scientists think of making them in the laboratory. So far, people have not succeeded, because these "characteristic" cells only maintain the characteristics of their stem cells in the natural environment, and if they are not there, they will "change their temperament." This achievement has taken a step toward the ultimate goal, which means that there will be a dawn in the future treatment of human leukemia. (Reporter Zhang Mengran)
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