A new capsule for the treatment of AIDS comes out, and long-term medication will benefit for a long time!
January 11, 2018 Source: medicalxpress Author: Heather_z727
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];[New drug capsules allow weekly HIV treatment] Researchers at NIH MIT and Brym Women's Hospital have developed a capsule that provides a single week of HIV medication. The researchers say this advancement will make it easier for patients to stick to the strict dosing schedule required for drug cocktail therapy against the virus.
The new capsule is designed so that the patient can only take it once a week, and the drug will be gradually released throughout the week. Researchers say that this type of delivery system not only improves patient compliance with treatment plans, but can also be used by people at risk of HIV infection to help them avoid infection.
"One of the main obstacles to the treatment and prevention of HIV is compliance," the researchers said. "Infrequent doses can increase compliance and have a significant impact at the patient level."
“We are very excited about this new drug delivery system that is likely to help people living with HIV and many other diseases. Since the introduction of antiretroviral therapy in the 1990s, the overall mortality rate of HIV has fallen dramatically, but in 2015 There are still 2.1 million new HIV infections and 1.2 million HIV-related deaths. Some large clinical trials have evaluated whether antiretroviral drugs can prevent HIV infection in healthy people. Although these trials have been successful, preventive treatment One of the main obstacles is getting people to take the necessary pills every day. The MIT/BWH team believes that the drug delivery capsules developed in 2016 may help solve this problem. Their capsules are made up of a star structure with six arms. Load the drug, fold it inward, and place it in a smooth coating. After swallowing the capsule, the arms unfold and gradually release their cargo."
In a previous study, the researchers found that these capsules could remain in the stomach for two weeks, gradually releasing the malaria drug ivermectin. The researchers then began to adjust the capsules to deliver HIV drugs. In its original version, the entire star was made of a polymer that provided both structural support and drug payload. This makes it more difficult to design new capsules because any change to the polymer composition can destroy the structural integrity of the capsule, thereby releasing the drug at a different rate.
To overcome this, the researchers devised a new version in which the backbone of the star structure is still a strong polymer, but each of the six arms can be filled with a different drug-loaded polymer. This makes it easier to design capsules that release the drug at different rates.
“In a way, it's like putting a pill in a capsule and having a chamber on a capsule every week. Experiments with pigs have shown that the capsule can successfully stay in the stomach and Three different HIV drugs are released within a week. After all the drugs are released, the capsules disintegrate into smaller components that can pass through the digestive tract."
Infection-infective researchers collaborated with the Institute of Disease Modeling in Washington, DC, to try to predict how much weekly medications can affect HIV infection. They calculated that the dose from daily dose to once a week could improve the efficacy of about 20% of HIV prophylactic treatment. When this figure was incorporated into a computer model of HIV transmission in South Africa, the model showed that between 200,000 and 800,000 new infections could be prevented in the next 20 years.
“Long-acting, non-invasive oral preparations may be an important part of our future. Significant advances have been made to advance antiretroviral therapy to enable people living with HIV to achieve near-normal life and reduce the risk of acquiring HIV. The lack of daily treatment for people living with HIV and pre-exposure prophylaxis (PREP) for uninfected high-risk populations remains a key challenge requiring new and improved HIV treatment and prevention tools, as well as wider implementation. New and existing approaches to end the HIV epidemic as we recognize it. Such research helps us get closer to achieving this goal."
Since the researchers designed the polymer arms of the capsules, it is easy to exchange different drugs in and out. In order to put other drugs on the system, the core system remains the same, all we need to do is change how slowly or how quickly it is released. Researchers are also investigating capsules that can stay in the body for long periods of time.
Original title: Breakthrough! A new capsule for the treatment of AIDS comes out, and long-term medication will benefit for a long time!
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