FDA officially started human liver chip test
Recently, the US FDA began a trial to test whether a special liver chip (livers-on-a-chip) can reliably mimic human foodborne diseases. This liver chip is a miniaturization of human organs. Models that mimic certain biological functions; this new test will help institutions determine whether certain companies can use chip data instead of animal toxicology when applying for approval of certain toxic compounds (such as food additives) Experimental data. At the same time, this is the first time that regulators in various parts of the world have used organ-based chip structures as an alternative to animal experiments.
Suzanne Fitzpatrick, senior adviser to the FDA's Food Safety Division for Toxicology, announced in a blog post that the new test will be launched on April 11. Although the chip is used for drug testing, Fitzpatrick's department hopes to use the chip to observe a single organ. How to deal with some products, such as dietary additives and cosmetics, and they will also test how food-borne pathogens affect organ function; FDA food safety scientists will evaluate this human liver chip for the first time, after which they will It will gradually advance to kidney chips, lung chips, and intestinal model chips.
The chip was developed by Boston biotech company Emulate, which includes many types of human liver cells that are born on the scaffold, while it continuously pumps out blood-like fluids through the system to transport nutrients and remove waste. Chief Executive Geraldine Hamilton said they can also add components of the immune system to the chip to test how it affects liver metabolism.
There is still a long way to go
University of Pittsburgh toxicologist Lawrence Vernetti said that I am very excited that people can try this new technology. Many aspects of animal metabolism are significantly different from humans. For example, chocolate is poisonous for dogs, even though animals usually have It is a good model that can help predict the organ toxicity of human tissues, but sometimes it is not reliable. If the long-term goal of the researchers is to reduce the number of animals used in animal experiments, then the chip system developed by the researchers may be able to provide great help.
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