Libella will develop the world's first genetic drug for Alzheimer's disease

Libella will develop the world's first genetic drug for Alzheimer's disease

January 12, 2018 Source: Sina Pharmaceutical

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Recently, it has been reported that Libella Gene Pharmaceuticals will conduct relevant clinical research in Cartagena (OUS), Colombia, relying on gene therapy to attempt to reverse the progress of age-related diseases. The initial target of the trial is Alzheimer's disease. Unlike traditional medicines that take months or years, gene therapy can solve the underlying problem of the disease at one time, repair the defective DNA in the patient's body and repair the body.

Currently, 228 Americans die every day from Alzheimer's disease, and there are no known treatments or drugs available worldwide. Gene therapy can permanently correct the disease and treat many diseases that are currently considered incurable. According to Dr. Andrew Andrews, a scientist in charge of the study, "human telomerase reverse transcriptase (hTERT) is an enzyme that plays a role in cellular senescence and is usually compressed in cells, causing telomeres to gradually shorten. Telomerase gene therapy can delay aging and increase longevity without increasing cancer."

The main role of telomerase is to lengthen the telomere length at both ends of the chromosome and maintain the stability of the chromosome (the vector of the gene). Telomere has a nickname called "Life Clock". Every time the human DNA divides and replicates, the telomere shortens. Once the telomere is depleted, the cell will immediately activate the apoptotic mechanism, that is, the cell will go to apoptosis. By inducing telomerase, Dr. Andrews and Libella hope to extend the telomeres of human cells. The safety of gene therapy treatment trials has been confirmed (more than 186 clinical trials have shown minimal adverse effects).

When asked why the company decided to conduct a clinical research project outside the United States, Dr. Jeff Mathis, president of Libella, said, “In the United States, traditional clinical trials can take years and cost millions or even billions of dollars. It has proven feasible. The technology is ready, we believe we have enough scientists, technicians, doctors and laboratory partners to believe that this test can be completed faster in Colombia.

The clinical trial is in preparation and is expected to begin in the first quarter of 2018 and will be conducted at the MediHelp service clinic (a beautiful tourist area in Cartagena, Colombia). With state-of-the-art facilities, it has hosted hundreds of international celebrities including athletes, celebrities and politicians. Dr. Javier Hernandez, Medical Director of MediHelp, will oversee the trial.

Colombia's clinical research regulations have maintained a friendly acceptance of gene therapy trials, and Latin America has the fastest time to approve such studies. The clinical research design, regulatory, operational and logistical support, project management, statistical analysis, and research monitoring services of the trial will be supported by Florida clinical research firm LATAM Market Access Inc. (Sina Pharmaceutical Compilation / Fan Dongdong)

Article Reference Source: Libella Gene Therapeutics' New Clinical Study May be the World's First Cure for Alzheimer's Disease

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