Osaka University, Japan invents the latest new technology: visualizing the bone absorption process
A research team at Osaka University in Japan recently invented a technique to observe the process of bone absorption in experimental mice in real time, which will help to study diseases related to bone development and metabolism.
According to a research report released by Osaka University, osteoclasts differentiated from hematopoietic stem cells are a component of bone tissue that dissolves aged bone cells and exerts bone resorption. Osteoclasts play an important role in the development and repair of bones. If the osteoclast is overactive, it may cause diseases such as osteoporosis and rheumatoid arthritis. A cell that functionally corresponds to osteoclasts is called osteoblast.
Professor Kikuto and et al. of Osaka University invented a fluorescence detection method. After the fluorescent substance is injected into the test body, the bone can be fluoresced only by the osteoclast, so that the living body can be observed with a special microscope. The process by which osteoclasts dissolve bones can also quantify the activity of osteoclasts.
The researchers believe that this technology will be used for early diagnosis of related diseases and for the observation of drug treatment effects of bone-related diseases. Relevant research results have been published in the monthly magazine Nature and Chemical Biology.
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