Release date: 2018-04-18
The reporter recently learned from the Shanghai Institute of Ceramics of the Chinese Academy of Sciences that the two researchers, Shi Jianlin and Chen Yu, first proposed the new concept of "nanocatalytic medicine" in the international authoritative review academic journal "Chemical Society Review", and this new method Applied in the efficient and safe treatment of tumors, it is expected to kill cancer cells with low toxicity and high efficiency.
Conventional tumor chemotherapy uses a cytotoxic drug with high cytotoxicity to simultaneously kill cancer cells and normal cells through a pathway of apoptosis or non-selective necrosis. Shi Jianlin said that if non-toxic/low-toxic nanoparticles can be used, a series of biology and diseases can be achieved by selectively catalyzing or triggering specific chemical reactions inside the tumor tissue to produce a considerable amount of specific reaction products locally. The physiology response, which may achieve tumor-specific treatment and imaging without significant side effects on normal tissues, to achieve specific cancer control goals. This is different from the traditional clinical cancer diagnosis and treatment mode, known as "nanocatalytic medicine."
Previously, the Shanghai Silicate Research team successfully prepared monodisperse magnesium silicide nanoparticles with a diameter of about 100 nanometers using an improved self-propagating combustion method. The specific micro-environment in response to the tumor is realized, and the oxygen molecules in the tumor are largely consumed, and the vascular system is blocked at the same time, and the supply of external oxygen molecules and nutrients is prevented, thereby achieving the effect of tumor-specific local hunger treatment.
The nanoparticles are stable in the neutral environment of normal tissues, non-toxic and harmless; and in the weak acidic environment of the tumor, they can react with protons to form silanes. This silane molecule reacts easily with oxygen molecules, thereby consuming large and rapid oxygen components; at the same time, the resulting silica intermediates block the blood vessels in situ, preventing the supply of external oxygen molecules and nutrients through the tumor vasculature. Thereby inhibiting tumor growth and achieving tumor treatment effect. Finally, these silica particles can also be completely degraded after a certain period of time, so that there is no toxic side effect at all.
In vivo animal experiments showed that this nanocatalyst had no adverse effects on healthy mice for three weeks, indicating that it has good in vivo biosafety. At present, 85.6% of the catalytic treatment of tumor efficiency has been achieved in the laboratory stage.
Source: Zhongqing Online
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