1. The pharmacological effects associated with efficacy
(1) Promote hematopoietic function
Subcutaneous injection of Shouwuye 0.2g twice daily for 3 days resulted in a significantly higher yield of granulocyte progenitors than in saline control. Intraperitoneal injection of 50 mg/kg of Radix Polygoni multiflori for continuous administration for 3 days resulted in a significant increase in bone marrow hematopoietic stem cells, a significant increase in the production rate of granulocyte-monocytic progenitor cells, and a significant increase in erythroid progenitor cells. .
(2) enhance immune function
Polygonum multiflorum had obvious antagonistic effects on the inhibitory changes of spleen and thymus in aged mice caused by prednisolone and cyclophosphamide, which significantly increased the phagocytosis rate and phagocytic index of splenic macrophages. Feeding Shouwu Ethanol Extract can significantly increase DNA damage repair ability of peripheral lymphocytes in aged rats. Mice fed the system of Shouwu 6g/kg, continuous administration of 7 days, can significantly increase the phagocytic capacity of peritoneal macrophages, the phagocytic index caused by prednisolone decreased, there is a clear confrontation.
(3) Hypolipidemic and anti-atherosclerosis
Rats with hyperlipidemia fed 4 g/kg of Radix Polygoni multiflori every day for 10 consecutive days could significantly reduce serum total cholesterol (TC) and serum triglyceride (TG) levels in rats. For hyperlipidemic sputum, continuous administration of Shouwu for 4 weeks can significantly reduce serum TC content and increase HDL/TC ratio. Another experiment proved that rabbits with hyperlipidemia and atherosclerosis, or fed with Polygonum multiflorum on the 7th, not only reduced the content of TC, but also reduced the formation of atherosclerotic plaque. When the water extract of Polygonum multiflorum extract 32g/kg was fed for one month, the HDL-C level could be significantly increased. The rats fed with feedstuffs of Polygonum multiflorum can also significantly increase HDL-C after 90 days, but there is no obvious change in TG and TC, and it has obvious inhibitory effect on β-lipoprotein. Polygonum multiflorum extracts were given intragastrically for rapid atherosclerotic plaque. For 6 consecutive weeks, plasma HDL-C/TC ratio was significantly increased, and the effect of high-dose group was more significant. Each administration group had the effect of delaying atherosclerosis. The effective components of the blood-thinning and anti-cholesterol effects of Polygonum multiflorum include quinones, diphenylene compounds, and lecithin.
(4) Liver protection
The diphenylene compounds contained in Polygonum multiflorum have obvious antagonistic effects on fatty liver and hepatic function of rats induced by peroxidized corn oil, elevated lipid peroxidation, elevated serum alanine aminotransferase and elevated aspartate aminotransferase, and serum Free fatty acids and hepatic lipid peroxide content decreased. Inhibition of lipid peroxidation of rat liver microsomes induced by ADP, NADPH in vitro. Heshouwu has also increased hepatic glycogen. Radix Polygoni multiflori, Radix Scutellariae Black Bean Juice, and steamed Radix Astragali decoction counteract the hepatic fat accumulation induced by prednisone acetate, which can reduce the hepatomegaly caused by CCl4 and reduce the liver weight coefficient.
(5) Anti-aging, modern investigations have vitamin E to prevent wrinkle regeneration.
Decoction of Polygonum multiflorum fed to aged mice or young mice can increase the protein content in the brain and liver and increase the DNA repair capacity of the elderly. what
Heshouwu
The ethanol extracts and aqueous extracts of Radix Polygoni multiflori can increase the protein and nucleic acid content of thymus in aged rats to varying degrees.
The anti-aging effect of Polygonum multiflorum is associated with anti-oxidation. Aged mice fed Heshouwu decoction concentrate can significantly increase the activity of SOD in blood. The concoction has certain influence on the antioxidation of Shouwu. Both the new processed products and the old processed products can obviously increase the activity of SOD in the whole blood and brain of mice, and can reduce the LPO in the heart, liver, brain and blood of mice. Content, raw materials have no significant effect on SOD and LPO. The Shouwu alcohol extract or water extract can improve the SOD content and reduce the LPO content in the heart, liver and brain of aged rats to varying degrees.
(6) Effect on endocrine
Heshou decoction concentrate can be administered to mice for a long time, which can increase the adrenal weight of mice. Polygonum multiflorum has similar functions to adrenocortical function. It can significantly increase the stress ability of mice with bilateral adrenal glands and reduce the mortality caused by freezing. Shouwu preparation promoted hepatic glycogen accumulation in norepinephrine starved mice and promoted the increase of hepatic glycogen. The effect of Polygonum multiflorum on the blood glucose has a certain time-effect relationship. The blood glucose rises to the peak within 30 and 60 minutes after oral administration of Shouwu decoction in rabbits, and then gradually declines. The blood glucose level is lower than normal after 6 hours. The rat liver insulin receptor has high affinity and low capacity, and low affinity and high capacity two receptors. The binding capacity of aged mice is significantly reduced, but the affinity is not changed. Polygonum multiflorum had no significant effect on both parameters of capacity and affinity.
(7) Laxative
The use of Polygonum multiflorum has a strong laxative effect, and the active ingredient chrysophanol can promote the intestinal movement of animals. Some patients with hyperlipidemia had increased stool frequency and diarrhea after taking them.
2. Other pharmacological effects
It has been reported that various processed products of Polygonum multiflorum (Shouwu, steamed Radix, black bean juice, steamed Radix, steamed Shouwu) are decocted against Staphylococcus aureus, Staphylococcus albus, Shigella flexneri, and Sungai. Shigella dysenteriae, Salmonella typhi 901. Paratyphoid bacillus from diphtheria bacilli, beta-hemolytic streptococcus, etc. have varying degrees. Inhibitory effect, which Shengshou decoction anti-Staphylococcus aureus effect is stronger than other processed products, system Shouwu decoction against Staphylococcus, steamed Shouwu decoction and Dihuang steamed Shouwu decoction against diphtheria The inhibitory effect of Bacillus is stronger than that of other Shouwu. Polygonum multiflorum has a certain inhibitory effect on influenza virus. In addition, Heshouwu has the effect of slowing heart rate, expanding coronary artery, and resisting myocardial ischemia.
In summary, the pharmacological effects related to the efficacy of Hexie polygonum multiflori, hepatic kidney, beneficial blood, black beard hair, and strong bones and muscles are to promote hematopoiesis, improve immune function, reduce blood fat, resist atherosclerosis, protect the liver, and delay aging. Affect endocrine function, laxative and other effects. The material basis of the efficacy of Polygonum multiflorum is mainly composed of phospholipids, terpenoids and glucosides.
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