Xenograft treatment for type 1 diabetes is expected to enter the clinic

Xenograft treatment for type 1 diabetes is expected to enter the clinic

September 11, 2017 Source: Technology Daily

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"Xenograft treatment of type I diabetes has basically achieved similar efficacy to human islet transplantation. The team plans to work with multiple hospitals to achieve the goal of completing 10,000 diabetes treatments per year after two years of work." September 8 , Changsha, Hunan Provincial Medical Association organized experts to review the “Clinical Study of Small Samples of Type I Diabetes in Newborn Porcine Islet Transplantation Treatment” approved by the Hunan Provincial Health Department in 2013. Professor of Xiangya Third Hospital of Central South University, Hunan Province Wang Wei, director of the Transplant Engineering Technology Research Center, said. This means that xenotransplantation is expected to enter the clinic, benefiting millions of ordinary patients.

International research suggests that human islet transplantation is currently the treatment that may cure diabetes. However, human-derived organ donors are extremely scarce, and the number of donors for human islet transplantation is extremely limited. In order to break through the bottleneck of donor shortage in islet transplantation, Wang Wei team conducted a 21-year study of xenograft pig islets. Up to now, it has won a series of world-leading system original results: in Ningxiang, Hunan, the world's second, Asia's first "biosafety donor pig breeding center", raising and cultivating medical use for porcine islet transplantation Grade donor "Sino pig"; established a world-leading large-scale high-efficiency porcine islet isolation and purification system and detection system, can scale production, extract large quantities of porcine islets, and ensure the purity and activity of islet extraction; first established in the world Porcine islet transplantation for the treatment of diabetes clinical technology system, designed a minimally invasive surgical program to protect the transplanted islets, effectively reduce the incidence of complications, effectively avoid bleeding clots "eat" the transplanted islets.

Wang Wei said that the new clinical islet transplantation treatment program can also transfer the regulatory T cells from the patients while transplanting islets, significantly reduce the rejection of transplanted islets in patients, and greatly reduce the anti-rejection drugs. Use the dose. Clinical results show that this innovative transplantation technology system is highly safe and effective. (Reporter Yu Huiyou correspondent Cao Xiya Yu Xi Jiang Kai)

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