Lymphatic dysfunction or decreased cognitive function in mice
August 01, 2018 Source: Chinese Journal of Science
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The meningeal lymphatic vessels are lymphatic networks that drain large molecules inside the central nervous system sheath. A mouse study published online in Nature recently showed that meningeal lymphatic dysfunction is an aggravating factor in Alzheimer's pathology and age-related cognitive dysfunction.
Previously, researchers have found lymphatic vessels in the meninges of rodents, non-human primates, and humans, but the role of lymphatic vessels in the central nervous system and in central nervous system diseases is unclear.
Jonathan Kipnis of the University of Virginia in the United States and colleagues confirmed that meningeal lymphatics can drain macromolecules from the cerebrospinal fluid and interstitial fluids of the central nervous system to the cervical lymph nodes. The researchers found that damage to meningeal lymphatic function in adult young rats leads to decreased learning and memory. In addition, the meningeal lymphatic function of aged mice is severely disrupted or causes some age-related cognitive dysfunction. After treatment with vascular endothelial growth factor C, the ability of the meningeal lymphatics to clear the macromolecules in the cerebrospinal fluid and interstitial fluid is enhanced, and the learning and memory ability is also improved.
In the Alzheimer's disease transgenic mouse model, impaired meningeal lymphatic function promotes amyloid deposition in the meninges, which is very similar to the meningeal pathology of human Alzheimer's disease. Researchers believe that enhancing meningeal lymphatic function can prevent or delay age-related neurological diseases. (Tang Yichen)
Related paper information: DOI: 10.1038/s41586-018-0368-8
Chinese Journal of Science (2018-08-01 2nd Edition International)
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