Rat and mouse anesthesia dose reference

IM: intramuscular injection IV: intravenous SC: subcutaneous injection IP: intraperitoneal injection  
Drug dosage route  
Pre-anesthesia administration  
Atropine  
0.002-0.005 mg/100 gBW  
0.12 mg/100 gBW  
IM, IV, SC*  
IP*  
sedative  
Acepromazine  
Diazepam  
Ketamine  
0.075 mg/100 gBW  
0.5 mg/100 gBW  
2.0 mg/100 gBW  
IM  
IP  
IM  
Injection of anesthetic  
Ketamine  


Pentobarbital  

Thiopental  

Thiamylal  
2.2-4.4 mg/100 gBW  
10 mg/100 gBW  
2.5 mg/100 gBW  
1.5 mg/100 gBW  
6.0 mg/100 gBW  
2.5 mg/100 gBW  
5.0 mg/100 gBW  
2.5-5.0 mg/100 gBW  
IM  
IP  
IV  
IV  
IP  
IV  
IP  
IV  
Mixed injection anesthetic  
Ketamine & Xylazine  

Fentanyl& Droperidol & Diazepam  


Ketamine & Acepromazine  
8.7 & 1.3 mg/100g BW  

0.2-0.5 ml/100g BW (10% solution)  
0.5 mg/100g BW  

2.2-4.4 & 0.075mg/100 g BW  
IM  

IM  
IP  

IM  
Inhalation anesthetic  
Methoxyflurane  


Halothane  


CO2  
Induction: 2-4%  
Maintenance: 0.5-1.5%  

Induction: 1-3%  
Maintenance: 0.5-1.5%  

Induction: 10-15seconds  
Analgesics  
Meperidine  

Pentacozine  
Nalbuphine  
Butorphanol  
Buprenorphine  
2.0 mg/100 gBW  
0.4 mg/100 gBW  
1.0 mg/100 gBW  
0.5 mg/100 gBW  
0.1-0.5 mg/100 gBW  
0.2 mg/100 g BW/12h  
0.2 mg/100 g BW/6-8h  
IM, SC  
IP  
IM, SC, IV  
IM, SC  
IM, SC  
SC  
IP  
Deprecated drug  
Chloroform  
Carbon tetrachloride Chlorpromazine  
Ether  
Trichloroethylene  
Tribromoethanol  


Drug dosage route  
Pre-anesthesia administration  
Atropine  
0.002-0.005 mg/100 gBW  
IM, IV, SC  

sedative  
Acepromazine  
Diazepam  
Xylazine  
Ketamine  
0.5 mg/100 gBW  
0.25 mg/100 gBW  
1.3 mg/100 gBW  
2.2 mg/100 gBW  
2.0 mg/100 gBW  
IM, SC  
IP  
IM  
IM  
IP  
Injection of anesthetic  
Fentanyl &Droperidol  
Ketamine  


Pentobarbital  
0.2-0.4 ml/kg (10% solution)  
4.4 mg/100 gBW  
4-16 mg/100 gBW  
5 mg/100 gBW  
3-4 mg/100 gBW  
3-5 mg/100 gBW  
IP  
IM  
IP  
IV  
IV  
IP  
Mixed injection anesthetic  
Ketamine & Xylazine  
Ketamine & Acepromazine  
Ketamine & Pentobarbital  

Innovar-Vet &Pentobarbital  

Inactin  
Acepromazine & Pentobarbital  

8.7 & 1.3 mg/100g BW  
2-4 & 0.075mg/100 g BW  
4.4 & 2.5 mg/100g BW  
6.0 & 2.1 mg/100g BW  
(I) 0.13-0.3 ml/kg (10% solution) & (P) 1-2 mg/100 g BW  
100mg/kg  
0.5 & 2.5-3mg/100 g BW  
IM  
IM  
(K)IM, (P)IP  
(K)IM, (P)IV  
(I)IM, (P)IP  

IP  
(A)IM, SC, (P)IP  
Inhalation anesthetic  
Methoxyflurane  

Halothane  

Enflurane  

Ether  
Induction: 2-4%  
Maintenance: 0.5-1.5%  
Induction: 1-3%  
Maintenance: 0.5-1.5%  
Induction: 3-4%  
Maintenance: 1-3%  
Apply 1-2ml of cotton to the chamber.  
Analgesics  
Meperidine  
Pentacozine  
Butorphanol  
Nalbuphine  
Buprenorphine  
0.3-0.5 mg/100 gBW  
0.2 mg/100 gBW  
0.05-2ml/kg  
0.1-0.2 mg/100 gBW  
0.01-0.05 mg/100gevery 12 hr  
IM, IV, IP  
IM, IV, SC  
IM, SC  
IM, SC  
SC  

Deprecated drug  
Chlorpromazine  
Chloralhydrate  
Chloroform  
Tribromoethanol  

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