Medical Network June 15th Chinese and American researchers published a paper in the new issue of the Proceedings of the National Academy of Sciences, revealing the assembly process of HIV particles. This discovery is expected to advance the development of AIDS treatment drugs and methods.
Researchers at Peking University and the Georgia Institute of Technology in the United States have used ultra-high-resolution "photosensitive positioning microscopy" to observe that the main structural protein of the most common HIV type "human immunodeficiency virus type 1" is group-specific under electrostatic action. The "antigenic antigen" is assembled in units of dimers or trimers and forms a tight assembly structure on the cell membrane.
The author of the paper and Chen Yushi, Department of Biomedical Engineering, Peking University School of Engineering, told Xinhua News Agency that the interaction between viral ribonucleic acid and group-specific antigens is a necessary condition for the smooth formation of HIV particles in the host cell membrane. The assembly of HIV particles is very important.
Chen Yushi said that in this process, the group-specific antigen and the viral ribonucleic acid are combined by electrostatic interaction, and the viral ribonucleic acid is used as a scaffold to polymerize a large amount on the host cell membrane, eventually forming thousands of virus particles.
Chen Yushi said that the HIV particles are only 150 nanometers in diameter. The latest research reveals the viral ribonucleic acid organization and regulates the complete assembly process of viral particles at the nanoscale.
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