[Chinese pharmaceutical network technology dynamics] Lung cancer is one of the fastest growing morbidity and mortality, and one of the most serious malignant tumors for people's health and life. In recent years, researchers have invested in lung cancer research. A research team led by Professor Kiyoshi Kenno (Immuno Biology) from Hokkaido University in Japan recently announced that they have successfully discovered a new mechanism for lung cancer cells to fight against cancer drugs by inhibiting immune cell activity. The results have been published in the well-known American journal of cancer. .
Researchers have found that a large number of macrophages that have the function of engulfing and destroying damaged tissues are concentrated around cancer cells with drug resistance, and most of these macrophages have the ability to inhibit the activity of other immune cells. The panelists investigated the relationship between the type of macrophage-inducible protein "Lnterleukin-34" and lung cancer cells.
The researchers co-cultured lung cancer cells with anti-cancer agents for 6 months, comparing the remaining drug-resistant lung cancer cells with common lung cancer cells. The investigation found that ordinary lung cancer cells do not secrete interleukin-34, while drug-resistant lung cancer cells secrete a large amount of interleukin-34. Drug-resistant lung cancer cells use interleukin-34 to transform macrophages into types that inhibit immune cell activity, thereby improving their ability to survive.
Mouse experiments have confirmed that by inhibiting the activity of interleukin-34, the therapeutic effect of anticancer drugs on drug-resistant lung cancer cells can be improved. Professor Qing Ye said that the proven mechanism of cancer cell resistance is completely different from the known mechanism and is of great significance for the development of new therapeutic drugs.
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