Release date: 2018-05-04
American scientists have discovered a protein that "feels" blood pressure and "informs" when small arteries expand, and is expected to treat ischemic stroke by activating this protein.
Published in the latest issue of the American Journal of Cell, "G-protein coupled receptor 68" (GPCR68) is a mechanical stimulator that is essential for the "blood flow-mediated expansion" function of the vascular system. Impaired "blood flow-mediated dilation" is a precursor to various cardiovascular diseases such as hypertension and atherosclerosis.
"G-protein coupled receptor" is a general term for a class of membrane protein receptors, and the study of this receptor was awarded the 2012 Nobel Prize in Chemistry.
The researchers designed a liquid turbulence that simulates blood flow. The instrument uses 384 pistons to squeeze cells in 384 slots by squeezing the liquid, then knocking out candidate genes for cells in each tank for screening. Finally, it was found that "G protein coupled receptor 68" has a pressure sensing function.
The researchers said that when the small arteries fail to expand properly, such as high blood pressure or vascular stenosis caused by atherosclerosis, the ability to lower blood pressure will be weakened, which may lead to ischemic stroke.
Adime Patabotian, a professor at the Scripps Research Institute and a senior author of the paper, said that the researchers next plan to study how to use small molecule drugs to regulate the function of this protein for clinical treatment.
Source: Xinhua News Agency
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