Release date: 2016-07-19
In patients with Parkinson's disease, falls can cause a variety of adverse consequences, such as weakness, depression, reduced quality of life, and even death. Postural control disorders are the most common cause of falls in patients with Parkinson's disease. Protective posture response plays a crucial role in preventing falls. When a patient is subjected to external disturbances (such as slipping or tripping), it is necessary to rely on a protective posture response to self-adjust.
Whether this process is affected by levodopa is not clear at present. Moreover, little is known about the role of levodopa in postural motor learning. Therefore, in order to determine the effect of levodopa on postural motor learning in patients with Parkinson's disease, Peterson et al. from the University of Utah in the United States designed the study and published the results in the online journal of Neurorehabil Neural Repair in May 2016. .
The investigators included 22 patients with Parkinson's disease who were trained for short-term external disturbances and assessed the protective posture response of patients with external disturbances during the onset and off-end phases of levodopa. . They also assessed the duration of this improvement process. The primary endpoint of this study was the shift in the patient's center of gravity after exposure to external disturbances. The secondary endpoint is the first step of the patient's response to external disturbances, including the stability of the foot margin when the first foot touches the ground.
The researchers found that after a short-term intervention training for the outside world (1 day training time). When these patients with Parkinson's disease are in the onset of levodopa, the shift in the center of gravity and the stability of the contour of the edge at the first touchdown are more significant, and when the patient is in the drug-off period, the improvement is not very good. obvious. Other pedestrian characteristic variables, such as step size and total number of steps, did not improve significantly. These improvements last for 24 hours, and the duration of the drug's action period is more pronounced in the stability of the edge when the foot touches the ground.
The results of this study indicate that in patients with Parkinson's disease, the protective posture response of these patients can be improved by short-term external disturbances, and this improvement is more pronounced when levodopa is active. Therefore, it is recommended to conduct external disturbance training in the case of applying levodopa, thereby enhancing the effect and duration of training and preventing the occurrence of falls in patients with Parkinson's disease.
Source: Lilac Garden
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