Pharmacological effects
The role of cardiovascular
Rana meliloti impregnated on the weak frog heart has increased myocardial contractility, anti-arrhythmia effect, but the role of normal isolated frog heart is not significant. It can also increase the myocardial contractility of dogs and rabbits, significantly expand blood vessels, reduce blood pressure, and the effect of leaves is stronger than that of roots and stems. Injection of R. edulis injection (0.25 g/ml) into isolated rabbit ears, forelimbs and hearts, increased cardiac flow, and the expansion of rabbit coronary vessels was stronger than that of rabbit ears and anterior and posterior limbs. Injection of R. edulis injections can also counteract the vasoconstrictive effects of norepinephrine and allow it to expand. With regard to the uptake of 86Rb in the mouse myocardium as an index, it was observed that extracts from the root of E. mellonella, alcohol extracts, ether extract III and ether extracts V and VI could increase the myocardial 86Rb uptake in mice to varying degrees. , It has the effect of improving myocardial nutrient blood flow. In addition, deer head grass decoction can also significantly increase the myocardial nourishing blood flow and tissue (liver, kidney, spleen, brain) blood flow, and can significantly increase plasma cAMP content.
Antibacterial effect
Decoction deer water has inhibitory effect on Staphylococcus aureus, hemolytic streptococcus, pneumococcus, meningococcus, Shigella flexneri, Salmonella typhi, and Pseudomonas aeruginosa. Salmonella typhi, Pseudomonas aeruginosa, Proteus, Shigella sonnei, and E. coli also all had inhibitory effects. The MICs were 12.5, 12.5-50, 20-50, 50, and 100 mcg/ml, respectively.
Antiprogestation
Female mice took deer grass decoction for 10 days every day, and the male mice were caged together for 1 month from the 5th day to inhibit fertility by 100%. Taking medicine for 10-30 days can suppress the estrus period and cause atrophy of the uterus and the ovaries.
Immunopromoting effect
Decoction of 50% deer can increase the formation of active E rosettes, the rosette formation rate was 34.5±1.48% at 1:20, and the normal rosette formation rate was 21.8±2.15%. Decoction of deer head grass can also promote lymphocyte transformation. The conversion rate at 1:20 reached 65.0±0.5%, while the conversion rate of saline control group was 1.0±0.5%. PHA control The conversion rate of the group (50 hemagglutination units) was 76.0 ± 1.0%.
Other effects
After oral administration, the bear rushes rapidly hydrolyzes in the body to produce hydroquinone. When combined with glucuronic acid, it can release hydroquinone in alkaline urine and has bactericidal action. However, treatment of urinary tract infections is not effective. In the small intestine of the voles and chickens, there is a co-active transport system of both arbutin and glucose. The affinity of the system for the above substances is enhanced by Na+ and inhibited by K+.
Clinical application
Clinically used for hemoptysis, blood stasis, functional uterine bleeding, postpartum abdominal pain, rheumatoid arthritis, chronic dysentery, allergic dermatitis, and paddy dermatitis. Pregnant women are not allowed.
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