Pharmacological effects
1. Lower blood viscosity effect: 1.1.
Effect of clotting time: Take 30 rats and weigh 300 ± 20g, and randomly divide them into 2 groups. Inject intraperitoneal injection of pangolin slice decoction (concentration: 10%) and equal volume of normal saline. After 1 hour, re-dosing. Then anesthesia with sodium pentobarbital was injected, blood was collected from the tail, slides, capillary clotting times, and capillary heights were measured. The results of this experiment indicate that the decoction of Chuanjiajia tablet significantly prolongs the clotting time of rats and reduces the blood viscosity of rats.
1.2. Effect on the clotting time of mice: Take 36 mice (18±2g) and randomly divide into 3 groups. Gavage pandan tablet decoction and equal amount of normal saline respectively. After 3 days, the retro-orbital venous plexus was taken. Blood, the clotting time was determined by capillary method. The experimental results showed that the decoction of Chuanshanzhong tablet can significantly prolong the clotting time and reduce the blood viscosity of mice.
2. Anti-inflammatory effect: take 84 mice, randomized, gavage pandanjia tablets decoction and saline, 1 week later, the left and right ear of the mouse is coated with croton oil (including croton oil 2%, Anhydrous ethanol (20%, anhydrous ether (78%)) caused inflammation and swelling. Four hours later, the mice were sacrificed. The two ears were quickly cut and washed with a round stainless steel circle with a diameter of 4mm. The difference is the actual swollen weight of the left ear and the swelling percentage is calculated. The results are shown in Table 4. The experimental results showed that the extracts and alcohol extracts of Chuanjiajia tablets all had obvious anti-palin oil-induced ear inflammation (P<0.01, P<0.05).
3. Effects on tolerance to normobaric hypoxia in mice: The cyclodipeptides VI and VII in pangolin tablets can increase the tolerance to normoxia in mice.
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