There is a new DNA structure in human cells
Release date: 2018-04-25
An artistic map of the internal i-primary DNA structure of cells.
Image source: Daily Science website
According to the US Daily Science website on the 23rd, Australian scientists have discovered a new DNA structure in the living cells of human body for the first time - the "DNA kink" called "i-motif". This suggests that in addition to the well-known double helix structure, human DNA has more complex structures that also influence our biological functions, and in-depth study will promote our understanding of DNA.
Daniel Crist, the head of the latest research and the Calvin Institute of Medicine, pointed out: "When most people think of DNA, there is a double helix in their minds, but new research reminds us that there are completely different DNA structures. The i-motif is the four-strand 'knot' of DNA, which is quite different from the double helix and is likely to be critical to our cells."
Although scientists have previously seen i-primers and conducted detailed studies, these i-motifs were found in test tubes rather than in living cells. In fact, whether the i-primary "knot" exists in all living things has been controversial, and the new findings make everything ambiguous.
To probe the i-primahead inside the cell, the research team developed an accurate tool—a fragment of an antibody molecule that can be accurately identified and closely attached to the i-primary. Using fluorescence techniques, they revealed the location of i-motifs in multiple human cell lines. The researchers said: "We can see these green spots appear and disappear over time, so we know that i-primitives are forming, dissolving, and reforming."
They also prove that, in most cases, the i-primitive form is formed at a specific moment in the "life cycle" of the cell, at which time the DNA has been "read". The i-prime appears in certain regions of DNA that control whether genes are turned on or off, as well as in telomeres that are critical to the aging process.
Researchers believe that i-primers may be related to gene opening and closing, and may also affect whether genes are "read" well.
They concluded by revealing that the new DNA structure in the cell is exciting and will help us truly understand DNA and its impact on health and disease.
The study was published in the latest issue of Nature and Chemistry.
Source: Technology Daily
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